Seborrhea buy Accutane

Seborrhea - genetically determined disorder characterized by dysfunction of the sebaceous glands, quantitative qualitative changes of sebum. Main pathogenetic importance breach of physiological balance between androgens and estrogens in the direction of the relative increase in the content of androgens how to get accutane. The connection of the functional state of the sebaceous glands with the pituitary changes, adrenal, thyroid, nervous system functional state, deficiency of vitamins Bl, B2, B6, biotin, enzymes - decarboxylase proteases.

There are dry, oily, thick, liquid and mixed seborrhea. When dry seborrhea sebum different refractoriness on the scalp flakes appear paraketoticheskogo character (dandruff). Their number gradually increases, they begin to spontaneously separate themselves falling clothes. Dry seborrhea sometimes accompanied by itching, marked dryness of hair thinning and loss, which can lead to baldness. The facial skin is dry, scaly, legkorazdrazhima.

It is now believed that a key role in the occurrence of seborrhea exposed skin and scalp plays a yeast fungus Pityrosporum ovale. The severity of disease is directly dependent on the amount of this fungus. It is used for treatment of these conditions Shampoo "Nizoral" (ketoconazole) has an etiological impact on the disease process.

Some patients may be mixed seborrhea: in some areas of the skin are the symptoms of dry, but on the other - oily seborrhea.

It should be noted that the presence of dry seborrhea is a risk factor for the development of eczematous process, while oily seborrhea predisposes to the formation of acne, hair zypadeniyu and so on. D.

The disease most often begins in puberty in girls earlier than in boys.

For oily seborrhea dramatically increases the amount of liquid secreted sebum. In liquid form it, spreading over the skin, giving it a greasy appearance. The hair becomes greasy, sticky, stick together, "hanging icicles." On the face visible expanded mouth of the hair follicles from which constantly secrete sebum. In the form of a thick appearing comedones - sebaceous plugs in the hair follicle and sebaceous gland excretory ducts. They consist of sebum, horny scales and dust and look like black spot. Dense form oily seborrhea is the background for the development of acne vulgaris.

Etiology and pathogenesis. In the development of the main key factors of acne are follicular hyperkeratosis, violation of keratinization processes, lipid imbalance, genetic predisposition, the increase in pathogenicity Propion bacterium and activity of the sebaceous glands, violation of circulating sex steroid hormones.

A certain role in the pathogenesis of acne belongs to dysfunction of the endocrine glands (pituitary, thyroid, adrenal cortex), dysfunction of the autonomic nervous system, digestive system, as well as hypovitaminosis and others. The cause dysfunction of the sebaceous glands, namely, their increased activity is often excessive allocation of androgens. Sometimes when in normal content marked hypersecretion of sebaceous glands. In this case, there is increased susceptibility of target organs, ie. E. The sebaceous glands, even to the normal amount of androgens. Hyperplasia of the sebaceous glands, excessive sebum, its qualitative change in the direction of increasing the content of free fatty acids leads to alkalization of the medium, follicular hyperkeratosis in the mouths of hair follicles and the enhanced reproduction of various microorganisms. Staphylococcus, Corynebacterium, propionbakterii cause inflammation of the sebaceous gland duct. However, the severity of inflammation depends not only on the absolute number of microorganisms involved in the inflammatory process, but also on the individual sensitivity of microorganism to microflora.