Schizophrenia added genes Use Seroquel

From Schizophrenia affects about every hundredth person in the world, and in recent years the risk of this disease among teenagers and 20-year-old young people is increasing buy seroquel online. The symptoms of schizophrenia are not limited to auditory and visual hallucinations, although they are the best known; patient greatly disturbed thinking and emotional reactions, because of what he ceases to perceive reality.

However, when it comes to pharmacological agents, it is still medicate schizophrenia, it is aimed at hallucinatory-delusional symptoms. Thinking and emotions such drugs are not reduced. Moreover, no fundamentally new compounds in this field does not appear from the 50s of the last century, and in terms of mechanism of action of all the modern means of antishizofrenicheskie have one goal - they act on proteins, one way or another related to the neurotransmitter dopamine.

Last but not least, this situation has developed with schizophrenia treatment because the causes of the disease remain unclear until the end. Of course, among the main suspects have been, and the genes for some time it was limited to only a few mutations that could explain only part of the clinical cases. To catch all the genetic problems that would need to be targeted to analyze the entire human genome.

Genetic research continued, and in the end, managed to identify 30 sites in all of human DNA, which in one way or another have been involved in the development of schizophrenia. However, recent work performed by a large research team from Harvard, MIT and Broad Institute is more than this figure covers - according to her, the number of genetic risk for schizophrenia zones equal 108. The study used the genetic data of about 37 000 patients with schizophrenia and 117,000 healthy people . The analysis took a few years, and as a result was able to find as many as 83 genomic regions which were associated with the disease, but that still no one paid attention.

But do not think that any anomaly of one hundred eight will lead to schizophrenia. According to the authors, each person can find dozens of "schizophrenic" mutations, but it is the patients will be more. That is the risk of disease should be evaluated according to the average weight of mutations, though, most likely, among them one can single out "a major" and "less than the principal."

Among the genes that can cause schizophrenia, as expected showed up those who are responsible for the formation of contacts and for the transfer of signals between nerve cells. However, other risk genes were not active in nerve cells, and immune, which indirectly confirms the well-known hypothesis about the infection as the possible cause of schizophrenia. Specific activity of immune genes, caused by a bacterium or virus, can affect the nervous system. On the other hand, the immune cells themselves may begin to attack the brain neurons, as occurs in autoimmune diseases.

However, the authors of the work are advised not to rush to the interpretation of the results. Genes that are active in immune cells, may play a role in the brain, and to talk about the causes of schizophrenia immune will be possible only after we learn that these genes are doing in the nervous system. But in any case it is obvious that even if only one judged by mutations, schizophrenia is spectacular multifactorial disease and its pharmacologic treatment should not be directed at a single target and a plurality. The results are published in the journal Nature.