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Candidiasis - the defeat of the skin, mucous membranes, nail plates and internal organs caused by the yeast-like fungi of the genus Candida does prednisone cause weight gain.

Currently, it is increasing the spread of opportunistic yeast fungi of the genus Candida (Monilia) among patients and healthy subjects, and there is an increased incidence of candidiasis of different ages of people.

Etiology. Yeast-like fungi of Candida genus (or Monilia) are imperfect fungi - Deuteromycetes (anaskosiorovym) - and represent a separate genus. The most common among patients with a form of C. albicans.

Yeast fungi species Candida albicans - celled microorganisms relatively large size, oval, round, sometimes oval-elongated. They form pseudomycelia (strands of elongated cells) blastospores (kidney cells sitting on banners pseudomycelia) and some chlamydospores - disputes with a double shell. The main features that differentiate Candida species from the true yeasts are the following: availability of pseudomycelia, no ascospores (dispute in bags inside the cells) and their inherent characteristic biochemical properties.

Epidemiology. The first meeting with fungi of the genus Candida often occurs in the first hours and days of life, and the data row and in utero. The possibility of fetal infection is confirmed by the detection of fungi in amniotic fluid, placenta, umbilical cord membranes. In the future infection of newborns is done in different ways: during the passage through the birth canal, with the mucous membranes of the mouth, when feeding, the skin of hands in the care of the skin of the nipple. Fungi of the genus Candida can enter the human body with household items, dishes, and food. There was a significant colonization by these fungi raw meat, dairy products, especially cheese curds, cottage cheese, sour cream, and fruit and vegetables. The source of the Candida infection, in addition to carriers and patients with candidiasis people may be domestic animals, especially young animals: calves, kittens, foals, as well as poultry.

Pathogenesis. Note that the entire genus Candida refers to opportunistic fungi, so in the pathogenesis of Candida infection belongs not so much to the pathogen as a microorganism of crucial importance. Nevertheless pathogenic fungi play a role in disease development. By pathogenic factors from fungi of the genus Candida are the secretion of proteolytic enzymes and hemolysin, dermatonekroticheskaya activity and adhesiveness (ability to attach to cells of the epithelium). It has been established that the strains Candida albicans pathogenic properties activated in the presence of various changes homeostasis.

Among the adverse factors of the environment should be made temperature conditions conducive to perspiration and maceration of the skin, to the skin and mucous membranes of the occupational hazards (acids, alkalis, cement, solvents), high concentrations of airborne fungal spores in a pastry production, hydrolytic production on protein synthesis ; trauma to the skin, especially on the canning industries where raw materials contaminated by these fungi; irrational hygienic regimen.

For groups that are prone to candidiasis are those of workers confectionery and canning industry, in which we have the maceration of the skin sweeteners and fruit juices, the impact of oxalic, malic, citric, lactic acids and alkalis, fruit essences, leading to injuries and skin maceration, the virulence of themselves yeast, are on good medium (for workers baths, baths, swimming pools, moyschits food supply), skin maceration housewives, maceration and action syrups sellers.

Endogenous factors are even more numerous. In the foreground metabolic diseases (diabetes, dysproteinemia, ulcerative colitis, goiter, obesity), a chronic infectious processes, diseases of the blood system, tumors, leprosy, myxedema, hyperthyroidism, Cushing's disease, vegetodistonii with excessive sweating, beriberi. In infants a significant role in the pathogenesis of candidiasis belong to reduced activity of serum fungistazy blood, which inhibits vital functions of the yeast flora and physiological deficiency and decreased salivation protivodrozhzhevoy activity of saliva lysozyme. The development of candidiasis in the first year of life of children, frequent regurgitation with reflux of acidic stomach contents into the mouth, which creates a favorable environment for the growth of Candida.