Pneumonia makes a hole in the heart Buy Amoxil

Pneumonia-causing bacterium penetrates through the blood vessels in the heart and damage the heart muscle that can cause arrhythmia and heart failure buy amoxicillin 250mg.

Pneumonia is often accompanied by problems with the heart, and the older a person is, the more serious they are: a quarter of the deaths from pneumonia is due to concomitant congestive heart failure or arrhythmias. Why pulmonary infection is so bad for the heart? The answer, at first glance, is clear: because of pneumonia impaired gas exchange, and the lack of oxygen to the heart is very, very sensitive. But this is not the only reason - researchers found the University of Texas Medical Center in San Antonio (USA), the causative agent of pneumonia, Streptococcus pneumoniae can harm the heart directly.

Carlos Orihuela (Carlos Orihuela) and his colleagues from a number of US and European research centers have found in mice hearts, rhesus monkeys and human damage caused to pnevmoniynoy bacterium. When pneumonia in mice troponin protein level increases markedly in the blood, which is contained in the cells of the heart and is involved in the reduction of the heart muscle. His appearance in the blood means that the myocardium is damaged. Electrocardiogram sick mice indicated arrhythmias (although it was shown in various animals to varying degrees), so that an occasion to look at the heart of the animals were ill with pneumonia, really was.

The authors of the article in PLOS Pathogens describe the tiny holes that could be found in the tissues of the heart (especially the ventricles), 30 hours after infection. Lesions were those blood vessels near the - apparently because the bacteria coming into the heart muscle with blood.

Similar ulcers occur in the heart in sepsis when organ tissues suffer from overactive immune system, but in the case of damage to pnevmoniynyh had no immune cells, but it had a lot of S. pneumoniae - obviously, the bacterium has learned somehow to deceive the immune system. At the same time in the cardiac muscle specimens from monkeys and humans, no bacteria was, probably, the researchers suggested for antibiotic treatment. If mice were given ampicillin antibiotic pneumonia, then 12 hours later, cardiac ulceration could find very little bacteria. On the other hand, the destruction of the bacteria has stimulated the activity of immune cells, which come to the heart and provoke scarring of tissue. When scarring normal tissue is replaced by connective body, and because of this had been ill with pneumonia may be heart problems even after the infection is gone from the body.

To finally confirm the role of infection in the occurrence of micro-holes in the heart muscle, the researchers infected mice with bacteria, deprived of protein adhesin CbpA. It bacteria need to pass through the cells covering the walls of blood vessels. In another embodiment, the experiment mice were given anti-cell receptor which normally binds CbpA - bacterial antibodies interfere with cellular protein interact. Finally, in the third embodiment, in animals disconnected receptor for platelet activating factor - without this again receptor bacteria can not penetrate into the host cell. In all three cases, the degree of infection of the heart damage dropped, although the number of bacteria was high. That is, microbes simply can not penetrate the heart and begin his "make a hole".

Obviously, in the treatment of pneumonia should be considered is the action of bacteria and try to help with what ever means to prevent microbial damage in the heart. The most amazing thing is that for the 120 years of the study is the first streptococcal pnevmoniynyh work, which refers to the penetration of S. pneumoniae in heart - until now for such damage for some reason did not pay attention.